Key result
Achieving complete left atrial roof line conduction block solely by cryoballoon ablation resulted in a higher 1-year atrial arrhythmia-free rate compared to other patients (80.6% vs 59.0%, p<0.01).
Why the study?
CBA of the LA roof in addition to PVI has been expected to improve post-AF ablation clinical outcomes, prompting evaluation of its characteristics and efficacy in a large-volume cohort.
Does achieving complete left atrial roof line conduction block solely by cryoballoon ablation improve 1-year atrial arrhythmia free rates in patients undergoing de novo AF ablation?
Cohort (n=834)
Does achieving complete left atrial roof line conduction block solely by cryoballoon ablation improve 1-year atrial arrhythmia free rates in patients undergoing de novo AF ablation?
Achieving complete left atrial roof line conduction block solely with cryoballoon ablation is feasible in the vast majority of cases and is associated with significantly improved 1-year freedom from atrial arrhythmias.
INTRODUCTION: Cryoballoon ablation (CBA) of the left atrial (LA) roof in addition to a pulmonary vein isolation has been expected to improve the clinical outcomes post-atrial fibrillation (AF) ablation. We demonstrated the characteristics and efficacy of CBA of the LA roof through our experience with a large volume of procedures. METHODS: Among 1036 AF ablation procedures with CBA of the LA roof, 834 patients who underwent a de novo ablation were analyzed. RESULTS: Complete LA roof line conduction block was obtained in 767 patients (92.0%) solely by CBA (Group A). Compared with the other patients (Group B), the mean nadir balloon temperature during CBA of the LA roof (-44.5 ± 5.6°C for Group A vs. -40.5 ± 7.5°C for Group B, p < .01) and number of cryoballoon applications during the LA roof ablation with a circular mapping catheter located in the left superior pulmonary vein (1.3 ± 0.8 for Group A vs. 1.6 ± 1.0 for Group B, p = .02) were significantly lower in Group A. A multivariate analysis revealed that those were predictors of a complete LA roof conduction block after only CBA. The 1-year Kaplan-Meier atrial arrhythmia free rate estimates were 80.6% for Group A and 59.0% for Group B (p < .01). CONCLUSION: Complete LA roof line conduction block could be obtained with a cryoballoon without touch-up ablation in most cases. The LA roof CBA with a circular mapping catheter located in the right superior pulmonary vein was preferable to obtaining complete LA roof conduction block, which was important with regard to the clinical outcomes.
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Shigeta et al. (2023) conducted a cohort in Atrial fibrillation (n=834). Cryoballoon ablation achieving complete LA roof line conduction block vs. Other patients (incomplete block solely by cryoballoon) was evaluated on 1-year atrial arrhythmia free rate (p=<0.01). Achieving complete left atrial roof line conduction block solely by cryoballoon ablation resulted in a higher 1-year atrial arrhythmia-free rate compared to other patients (80.6% vs 59.0%, p<0.01).
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