Key result
Crizotinib and chemotherapy shrink disseminated ALK-positive histiocytosis before fatal intracranial infection at 8 months.
Why the study?
ALK-positive histiocytosis is a rare disorder that can affect multiple systems, with only 10 cases previously reported invading the central nervous system.
Case Report (n=1)
No
ALK-positive histiocytosis can disseminate intracranially and should be considered in the differential diagnosis of suprasellar lesions in children, though treatment may be complicated by fatal infections.
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ALK-positive histiocytosis merits consideration in pediatric suprasellar differentials; this case extends sparse evidence on targeted therapy while underscoring infection risks.
Guo et al. (2022) conducted a case report in ALK-positive histiocytosis (n=1). Partial resection, chemotherapy (CHOP regimen), and crizotinib was evaluated on Tumor dynamic changes and survival. An 18-month-old boy with cerebrum-disseminated ALK-positive histiocytosis experienced gradual tumor shrinkage with crizotinib and chemotherapy but died 8 months after surgery due to intracranial infection.
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