Key result
Targeting brain endothelial cell death emerges as a promising therapeutic strategy in cerebral ischemic stroke.
This review explores the mechanisms underlying brain endothelial cell death in ischemic stroke and the potential application of protective drugs.
Brain endothelial cells (BECs) are situated at the interface between the bloodstream and the brain, serving a crucial function in the development and maturation of the brain, particularly in upholding the integrity of the blood-brain barrier (BBB). Consequently, any modifications or gradual breakdown of the endothelium can significantly disrupt brain homeostasis. Ischemic stroke (IS), characterized by the progressive compromise of the BBB and increased BECs mortality, stands as a prominent global cause of mortality and disability. This review will utilize recent research to explore mechanisms underlying death.
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Yi et al. (2025) conducted a review in Cerebral Ischemic Stroke. Protective drugs was evaluated. This review explores the mechanisms underlying brain endothelial cell death in cerebral ischemic stroke and the potential application of protective drugs.
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