What question did this study set out to answer?

To determine whether administration of liposome-bound fatty acid binding protein protects isolated rat hearts against ischemia-reperfusion injury.

June 1, 1990Circulation Research

Protective role of intracoronary fatty acid binding protein in ischemic and reperfused myocardium.

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To determine whether administration of liposome-bound fatty acid binding protein protects isolated rat hearts against ischemia-reperfusion injury.
Isolated rat hearts were preperfused with 1.4 µM liposome-bound fatty acid binding protein for 15 minutes.
Treated hearts were subjected to 30 minutes of global ischemia followed by 30 minutes of reperfusion and compared to untreated control hearts.
Treatment with fatty acid binding protein better preserved myocardial high-energy phosphates (ATP and creatine phosphate) and improved coronary flow relative to untreated controls.
Protein administration reduced cardiac release of creatine kinase and lactate dehydrogenase, enhanced arachidonic acid reacylation into phospholipids, and decreased free fatty acid accumulation.
Treated hearts demonstrated increased cytosolic concentrations of fatty acid binding protein-bound long-chain free fatty acids, thioesters, and carnitine esters.

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Implication

Preclinical ex vivo study demonstrates reduced tissue injury and preserved energetics in ischemic rat hearts, suggesting fatty acid binding protein as a potential therapeutic agent.

Cite This Study

Srimani et al. (1990) studied this question.

synapsesocial.com/papers/6a110e3bc56c5252651a22c8 https://doi.org/10.1161/01.res.66.6.1535

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Implication

Preclinical ex vivo study demonstrates reduced tissue injury and preserved energetics in ischemic rat hearts, suggesting fatty acid binding protein as a potential therapeutic agent.

Protective role of intracoronary fatty acid binding protein in ischemic and reperfused myocardium.

Key Points

Discussion

Implication

Cite This Study

Protective role of intracoronary fatty acid binding protein in ischemic and reperfused myocardium.

Key Points

Discussion

Implication

Cite This Study

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