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January 1, 2026Journal of Advanced ResearchOpen Access

Lactylation regulates cardiovascular disease via histone and non-histone modifications, exposing novel therapeutic targets.

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Design

Review

Key result

Lactylation functions through histone and non-histone modifications to orchestrate context-dependent dichotomies across cardiovascular diseases, presenting novel therapeutic vulnerabilities.

Authors

GCGuiling ChengYLYan LiuYXYangkun Xing

Discussion

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Member takes

Overview

Positions lactylation as a CVD therapeutic axis; leaves open mechanistic and clinical validation.

PICO

P
Population
Cardiovascular diseases
I
Intervention / Comparator
Lactylation modulation

This review establishes a translational framework for targeting the metabolic-epigenetic axis of lactylation in cardiovascular diseases.

Limitations

  • Incomplete characterization of the cardiovascular lactylome
  • Absence of selective pharmacological modulators
  • Insufficient understanding of how lactylation effects vary across cell types, disease stages, and metabolic contexts

Cite This Study

Cheng et al. (2026) conducted a review in Cardiovascular diseases. Lactylation modulation was evaluated. Lactylation functions through histone and non-histone modifications to orchestrate context-dependent dichotomies across cardiovascular diseases, presenting novel therapeutic vulnerabilities.

synapsesocial.com/papers/6a110e3c216a46d7d51a20cahttps://doi.org/10.1016/j.jare.2026.01.007
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