Key result
Patients with acute large artery ischemic stroke and prolonged QTc exhibited significantly higher hydrogen peroxide levels (40.10 vs 31.76 uM/L) and greater sympathetic drive than those with normal QTc.
Why the study?
Does neurovascular oxidative stress and autonomic modulation correlate with QT interval variations in patients with acute large artery ischemic stroke?
Observational (n=65)
Single-blind
No
Does neurovascular oxidative stress and autonomic modulation correlate with QT interval variations in patients with acute large artery ischemic stroke?
Absolute Event Rate: 40.1% vs 31.76%
p-value: p=<0.05
In acute large artery ischemic stroke, prolonged QTc intervals are associated with increased oxidative stress (elevated H2O2) and a predominant sympathetic autonomic drive.
QTc prolongation may signal heightened oxidative stress in acute stroke; this observational link leaves open causal implications for management.
Background: Acute stroke can disturb autonomic regulation and promoting oxidative stress. Prolongation of QT interval is very common in stroke and related with stroke recurrent and sudden death. In this study, we hypothesize that neurovascular oxidative stress and autonomic modulation contribute to QT interval variation.
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Kesorn Suwanprasert (2017) conducted an observational in Acute large artery ischemic stroke (n=65). Long QTc (LQTc) vs. Normal QTc (NQTc) and Short QTc (SQTc) was evaluated on Plasma hydrogen peroxide (H2O2) concentration (uM/L) (p=<0.05). Patients with acute large artery ischemic stroke and prolonged QTc exhibited significantly higher hydrogen peroxide levels (40.10 vs 31.76 uM/L) and greater sympathetic drive than those with normal QTc.
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