Intravenous dexamethasone 10 mg transiently increased blood glucose at 2 and 4 hours post-administration compared to saline (P<0.05), but levels returned to baseline by postoperative day 1.
RCT (n=60)
Double-blind
1:1 block randomization
No
Does a single intraoperative dose of intravenous dexamethasone increase perioperative blood glucose levels or improve postoperative recovery in diabetic patients undergoing thoracoscopic surgery?
A single 10 mg dose of intravenous dexamethasone in diabetic patients undergoing thoracoscopic surgery causes a transient increase in blood glucose up to 4 hours post-administration without increasing the need for additional insulin, while improving postoperative pain and recovery.
p-value: p=<0.05
This study aimed to investigate the effects of dexamethasone on blood glucose in diabetic patients undergoing thoracoscopic surgery, providing a reference for its safe intraoperative use in this population. In this randomized, double-blind controlled trial, 60 diabetic patients with reasonably controlled blood glucose (HbA1c 0.05). Compared with the control group, the experimental group showed higher blood glucose at 2 h and 4 h post-administration (P 0.05). The incidence of hyperglycemia (all time points) and additional insulin use showed no significant differences between groups (P > 0.05). The experimental group had lower VAS pain scores at 2 h postoperatively and on POD 1, 2, and 3 (P 0.05). Dexamethasone can be safely used in diabetic patients with reasonably controlled blood glucose (HbA1c < 9%) undergoing thoracoscopic surgery and the drug can effectively improve postoperative recovery.
Yang et al. (Wed,) conducted a rct in Type 2 diabetes mellitus undergoing thoracoscopic surgery (n=60). Dexamethasone vs. Normal saline was evaluated on Blood glucose levels at 2 h and 4 h post-administration, and on postoperative days 1, 2, and 3 (p=<0.05). Intravenous dexamethasone 10 mg transiently increased blood glucose at 2 and 4 hours post-administration compared to saline (P<0.05), but levels returned to baseline by postoperative day 1.