Neuroprotective effects of basil extract (Ocimum gratissimum) on hippocampal neuronal loss and spatial memory in a streptozotocininduced experimental Alzheimer’s disease model in rats using the Eight-arm Radial Maze Test

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This research aims to evaluate the neuroprotective effects of basil extract on hippocampal neurons and learning behaviors in a rat model of Alzheimer's disease.
Thirty-three 4-month-old male Wistar rats were divided into control, sham, STZ, O. gratissimum, and O. gratissimum+STZ groups.
The eight-arm radial maze test was used to assess learning behaviors post-treatment with STZ and basil extract.
Apoptotic cells in the hippocampus were quantified using the TUNEL method after histological analysis.
Rats treated with O. gratissimum showed a statistically significant improvement in learning behaviors compared to those with STZ alone (p<0.05).
The number of apoptotic cells in the hippocampus was reduced in the O. gratissimum group, indicating potential neuroprotective effects.

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Demonstrates improved learning behaviors in rats with Alzheimer's, suggesting potential benefits of basil extract.

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Aygün et al. (2026) studied this question.

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