Clinical Findings, Treatment Recommendations, and Outcome in Dogs Following Ingestion of a Single Unintended Dose of Trilostane: 403 Cases (2008–2023)

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Key Points

To characterize clinical signs and outcomes in dogs after accidental ingestion of trilostane and to describe treatment recommendations.
Retrospective evaluation of 403 canine cases from 2008 to 2023
Data collection included exposure history, clinical signs, and outcomes
Utilized ASPCA AnTox database for case selection
41 dogs (10.2%) showed clinical signs after trilostane exposure, most commonly vomiting (41.5%), lethargy (36.6%), and diarrhea (17.0%)
93.5% of follow-up cases (188/200) reported no symptoms from acute exposure
Dogs exhibiting clinical signs had a median exposure dosage of 13.2 mg/kg, significantly higher than those without signs (3.3 mg/kg)

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Retrospective evaluation characterizes outcomes following accidental trilostane ingestion in dogs, suggesting mild effects and low treatment needs.

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Summers et al. (2026) studied this question.

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