Key result
Lipoprotein lipase is the primary enzyme responsible for the conversion of lipoprotein triglyceride into free fatty acids, and its genetic variations are linked to conditions like chylomicronemia and atherosclerosis.
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This review summarizes the physiological, biochemical, and molecular biological roles of lipoprotein lipase, including its genetic variations and links to human disease.
Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in normal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized.
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J. Goldberg Ira (2001) conducted a review in Lipoprotein lipase physiology and genetic variations. Lipoprotein lipase is the primary enzyme responsible for the conversion of lipoprotein triglyceride into free fatty acids, and its genetic variations are linked to conditions like chylomicronemia and atherosclerosis.
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