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January 4, 2023Frontiers in GeneticsOpen Access

How many missed abortions are caused by embryonic chromosomal abnormalities and what are their risk factors?

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This study aims to determine how many missed abortions are caused by embryonic chromosomal abnormalities and identify their risk factors.
Investigated 131 women with missed or non-missed abortions from the Longitudinal Missed Abortion Study (LoMAS)
Conducted logistic regression analysis to associate maternal factors with chromosomal abnormalities
Collected data on maternal and embryonic characteristics.
Chromosomal abnormality rate was 3.9% in non-missed abortion embryos and 64.8% in missed-abortion embryos.
Assisted reproductive technology increases risk of abnormalities by 1.637 times (95% CI: 1.573, 4.346; p = 0.010)
Each additional year of maternal age increases the risk of abnormalities by 14.4% (OR: 1.144, 95% CI: 1.030, 1.272; p = 0.012).

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Randomized trial examines embryonic chromosomal abnormalities in missed abortions, suggesting key maternal risk factors.

Li et al. (2023) studied this question.

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