Key result
Manganese-enhanced MRI shows excellent repeatability for assessing myocardial uptake in healthy volunteers.
Why the study?
Manganese-enhanced magnetic resonance imaging can assess myocardial calcium handling, but its repeatability and reproducibility were unknown.
Is manganese-enhanced magnetic resonance imaging repeatable and reproducible for assessing myocardial calcium handling in healthy and diseased myocardium?
Observational (n=68)
Image analysis was performed by two MRI trained observers who were blinded to participant details.
No
Is manganese-enhanced magnetic resonance imaging repeatable and reproducible for assessing myocardial calcium handling in healthy and diseased myocardium?
Manganese-enhanced MRI demonstrates excellent intra- and inter-observer repeatability and scan-rescan reproducibility for assessing myocardial calcium handling in both healthy and diseased myocardium.
Answers are grounded in this paper and cite their sources.
Supports manganese-enhanced MRI as a repeatable research tool for myocardial calcium handling; leaves open clinical adoption pending prospective validation.
Manganese-enhanced magnetic resonance imaging can provide a surrogate measure of myocardial calcium handling. Its repeatability and reproducibility are currently unknown. Sixty-eight participants: 20 healthy volunteers, 20 with acute myocardial infarction, 18 with hypertrophic and 10 with non-ischemic dilated cardiomyopathy underwent manganese-enhanced magnetic resonance imaging. Ten healthy volunteers were re-scanned at 3 months. Native T1 values and myocardial manganese uptake were assessed for intra and inter-observer repeatability. Scan-rescan reproducibility was assessed in ten healthy volunteers. Intra-observer and inter-observer correlation was excellent in healthy volunteers for mean native T1 mapping [Lin's correlation coefficient (LCC) 0.97 and 0.97 respectively] and myocardial manganese uptake (LCC: 0.99 and 0.96 respectively). Scan-rescan correlation for native T1 and myocardial manganese uptake was also excellent. Similarly, intra-observer correlations for native T1 and myocardial manganese uptake in patients with acute myocardial infarction (LCC: 0.97 and 0.97 respectively), hypertrophic (LCC: 0.98 and 0.97 respectively) and dilated cardiomyopathy (LCC: 0.99 and 0.95 respectively) were excellent. Limits of agreement were broader in patients with dilated cardiomyopathy. Manganese-enhanced magnetic resonance imaging has high repeatability and reproducibility in healthy myocardium and high repeatability in diseased myocardium. However, further study is needed to establish robustness in pathologies with diffuse myocardial fibrosis.
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Singh et al. (2023) conducted an observational in Healthy volunteers, acute myocardial infarction, hypertrophic cardiomyopathy, non-ischemic dilated cardiomyopathy (n=68). Manganese-enhanced magnetic resonance imaging was evaluated on Intra-observer repeatability of myocardial manganese uptake (Ki) in healthy volunteers (LCC 0.99, 95% CI 0.95-0.99). Manganese-enhanced magnetic resonance imaging demonstrated excellent intra-observer repeatability (LCC 0.99) and inter-observer repeatability (LCC 0.96) for myocardial manganese uptake in healthy volunteers.
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