Key result
Female sex was not associated with an increased long-term risk of death compared with men after CABG in adults ≤50 years when adjusting for risk factors (HR 1.02; 95% CI 0.83-1.26).
Why the study?
Prior research showed higher mortality in women with severe coronary artery disease versus men, especially in younger patients, but whether this stems from an adverse risk factor profile was unknown.
Does female sex independently increase the risk of mortality in adults ≤50 years of age undergoing coronary artery bypass grafting?
Cohort (n=5,446)
Yes
Does female sex independently increase the risk of mortality in adults ≤50 years of age undergoing coronary artery bypass grafting?
Effect estimate: HR 1.02 (95% CI 0.83-1.26)
The higher unadjusted mortality risk observed in young women undergoing CABG compared to men is driven by a higher burden of baseline cardiovascular risk factors rather than female sex itself.
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Comorbidities, not sex, appear to drive excess mortality in young women post-CABG; leaves open whether targeted risk-factor modification improves outcomes.
Dalén et al. (2019) conducted a cohort in Coronary artery disease (n=5,446). Female sex vs. Male sex was evaluated on Risk of death (HR 1.02, 95% CI 0.83-1.26). Female sex was not associated with an increased long-term risk of death compared with men after CABG in adults ≤50 years when adjusting for risk factors (HR 1.02; 95% CI 0.83-1.26).
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