Key result
Extracranial carotid calcification shows no link to brain amyloid-β deposition in older adults without dementia.
Why the study?
ECAC is a known CVD risk factor associated with dementia and Alzheimer's disease, but its relationship with brain Aβ deposition in older adults is not fully understood.
Does extracranial carotid artery calcification associate with amyloid-β deposition in very old adults without dementia?
Cross-Sectional (n=90)
No
Does extracranial carotid artery calcification associate with amyloid-β deposition in very old adults without dementia?
In very old adults without dementia, extracranial carotid artery calcification is not significantly associated with intracranial amyloid-β deposition, suggesting alternative mechanisms may link atherosclerosis to cognitive decline in this population.
Background: Extracranial carotid artery calcification (ECAC) is a known risk factor for the development of cardiovascular diseases (CVD) and has been associated with an increased risk of dementia and Alzheimer's disease. However, the relationship between ECAC and amyloid-β (Aβ) deposition in older adults has not been fully understood. Objective: This study aims to determine the relationship between ECAC and Aβ deposition in very old adults. Methods: C-labeled Pittsburgh compound-B positron emission tomography (PiB-PET) scans performed in 2009 and 2011. Carotid artery plaque and ECAC status were measured via high-resolution carotid ultrasonography in 2011. Results: Among the participants, 82 (91%) had carotid plaques, and 46 (51%) were globally Aβ positive by PiB-PET. ECAC was less frequently observed in the Aβ positive group compared to the Aβ negative group (90% versus 81%, p = 0.3). The odds of Aβ positivity in those with ECAC were 62% lower than in those without ECAC. However, the association was not statistically significant (OR = 0.38, 95% CI: [0.08, 1.76 ], p = 0.2). Conclusions: In the population whose average age is older than 85 without dementia, there is no statistically significant association between ECAC and Aβ deposition after adjusting for confounding factors. The relationship between ECAC and dementia in older adults warrants further analysis in a larger and more racially and ethnically diverse population.
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Li et al. (2025) conducted a cross-sectional in Very old adults without dementia (n=90). Extracranial carotid artery calcification vs. No extracranial carotid artery calcification was evaluated on Amyloid-β (Aβ) positivity by PiB-PET (OR 0.38, 95% CI 0.08, 1.76, p=0.2). Extracranial carotid artery calcification was not significantly associated with brain amyloid-β deposition in very old adults without dementia (OR 0.38, p=0.2).
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