A double γ-cyclodextrin host bridged with a disulfide bond included two molecules of methyl orange with an association constant (1.06×1011 M−2) which is the largest value ever reported for 1 : 2 (host : guest) bindings of γ-cyclodextrin, demonstrating the collaboration of the two cyclodextrin parts on guest binding.
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Fujita et al. (1985) studied this question.
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