Poor sleep quality was positively associated with increased 10-year cardiovascular risk (P<0.001), an effect that was partially mediated by dietary inflammation (mediated proportion 14.6%).
Cross-Sectional (n=5,594)
Does dietary inflammation mediate the relationship between sleep quality and 10-year cardiovascular disease risk?
Dietary inflammation partially mediates the association between poor sleep quality and increased 10-year cardiovascular disease risk, suggesting that an anti-inflammatory diet may help mitigate cardiovascular risk in individuals with sleep disorders.
Effect estimate: 14.6% mediated proportion
p-value: p=<0.001
Objective: People with poor sleep quality have higher risk of cardiovascular disease (CVD), and one potential mechanism of CVD is chronic inflammation. The aim of this study was to investigate the role of dietary inflammation in the relationship between sleep quality and CVD risk. Methods: This study involved 5594 participants from the National Health and Nutrition Examination Survey (NHANES) in 2005– 2008. Sleep quality, dietary inflammation, and 10-year CVD risk were evaluated via the Pittsburgh Sleep Quality Index (PSQI), the Energy-adjusted Dietary Inflammatory Index (E-DII), and the Framingham Risk Score (FRS), respectively. We used generalized additive model (GAM) and mediation analysis to investigate the relationship among sleep quality, 10-year CVD risk, and E-DII. Results: PSQI had a non-linear relationship with 10-year CVD risk ( P < 0.001). Meanwhile, among the participants with poor sleep quality, PSQI was positively associated with increased 10-year CVD risk ( P < 0.001) and E-DII ( P < 0.001). Furthermore, the association between sleep quality and CVD risk was partially mediated by E-DII, and the mediated proportion was 14.6%, and the mediating effect of E-DII varied in different gender and age groups. However, in the subjects with good sleep quality, the association among PSQI, E-DII, and 10-year CVD risk was not existed. Conclusion: Ten-year CVD risk could be reduced by controlling the intake of inflammatory food, especially for whom with sleep disorders. In general, the reduction of inflammatory diet could weaken the effect of sleep disorders on the CVD risk. Keywords: inflammatory diet, sleep quality, cardiovascular disease, NHANES, mediation
Wang et al. (Tue,) conducted a cross-sectional in Cardiovascular risk (n=5,594). Sleep quality and dietary inflammation was evaluated on 10-year CVD risk (14.6% mediated proportion, p=<0.001). Poor sleep quality was positively associated with increased 10-year cardiovascular risk (P<0.001), an effect that was partially mediated by dietary inflammation (mediated proportion 14.6%).