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October 10, 1999Human Gene Therapy

Gene Transfer into the Liver of Nonhuman Primates with E1-Deleted Recombinant Adenoviral Vectors: Safety of Readministration

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Authors

FNFrederick A. NunesHospital of the University of PennsylvaniaEFEmma E. FurthUniversity of Pennsylvania
James M. Wilson
James M. WilsonThe Wistar Institute

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Nunes et al. (1999) studied this question.

synapsesocial.com/papers/6a11d7dc3f4fe1a84cb4ca6bhttps://doi.org/10.1089/10430349950016852
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs1996 · 263 citations
  2. 2Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy1996 · 377 citations
  3. 3An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer.1993 · 146 citations
  4. 4Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo.1995 · 259 citations
  5. 5Prolonged Transgene Expression in Cotton Rat Lung with Recombinant Adenoviruses Defective in E2a1994 · 209 citations