Key result
Translating clinical trial results into gain in disease-free life expectancy better reflects the actual effect of treatment for chronically progressive diseases than number needed to treat.
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Suggests that treatment effects for chronically progressive diseases should be expressed as gain in disease-free life expectancy rather than numbers needed to treat.
Treatment effects from randomised trials are typically expressed as numbers needed to treat to prevent one adverse disease event during a fixed time interval (eg, five or 10 years). In the actual patient, however, many diseases are chronically progressive, despite treatment. Examples are diabetic nephropathy, some types of malignancies, osteoporosis, and atherosclerosis. In these examples, the aim of treatment is not to prevent but to delay the occurrence of symptomatic disease. Thus the actual effect of treatment is gain in disease-free life expectancy
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Dorresteijn et al. (2016) studied Chronically progressive diseases. Translating clinical trial results into gain in disease-free life expectancy better reflects the actual effect of treatment for chronically progressive diseases than number needed to treat.
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