Key result
Review outlines current medical therapies and tailored management for cardiogenic shock and underlying cardiomyopathies.
Why the study?
Recent improvements have changed the landscape of cardiogenic shock, prompting a review of current medical treatments in light of recent literature.
This review provides an overview of current medical treatments for cardiogenic shock, focusing on inotropes, vasopressors, immunomodulation, and tailored management for specific cardiomyopathies.
May inform individualized cardiogenic shock management; leaves open optimal immunomodulation strategies pending prospective trials.
Cardiogenic shock (CS) is a leading cause of mortality worldwide. CS presentation and management in the current era have been widely depicted in epidemiological studies. Its treatment is codified and relies on medical care and extracorporeal life support (ECLS) in the bridge to recovery, chronic mechanical device therapy, or transplantation. Recent improvements have changed the landscape of CS. The present analysis aims to review current medical treatments of CS in light of recent literature, including addressing excitation-contraction coupling and specific physiology on applied hemodynamics. Inotropism, vasopressor use, and immunomodulation are discussed as pre-clinical and clinical studies have focused on new therapeutic options to improve patient outcomes. Certain underlying conditions of CS, such as hypertrophic or Takotsubo cardiomyopathy, warrant specifically tailored management that will be overviewed in this review.
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Lescroart et al. (2023) conducted a review in Cardiogenic shock. Medical treatments (inotropes, vasopressors, immunomodulation) was evaluated. Current medical treatments for cardiogenic shock, including inotropes, vasopressors, and immunomodulation, are reviewed alongside tailored management for specific underlying cardiomyopathies.
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