Key result
IL-10-producing regulatory B cells play vital immunomodulatory roles in CVD.
Why the study?
The interplay between B10 cells and the cardiovascular and immune systems is complex and requires clarification, as challenges hinder B10 cells from regulating immunoreactivity in specific cardiovascular diseases.
This review highlights the immunomodulatory roles and therapeutic potential of IL-10-producing regulatory B cells in various cardiovascular diseases.
May guide Breg-targeted immunomodulation in CVD; leaves open mechanisms and clinical translation.
Interleukin-10-producing regulatory B (B10) cells mediate the immunomodulatory functions of biosystems by secreting anti-inflammatory factors, thus playing vital roles in cardiovascular diseases such as viral myocarditis, myocardial infarction, and ischemia-reperfusion injury. However, several challenges hinder B10 cells from regulating the immunoreactivity of organisms in specific cardiovascular diseases, such as atherosclerotic disease. Regarding the regulatory mechanisms of B10 cells, the interplay between B10 cells and the cardiovascular and immune systems is complex and requires clarification. In this study, we summarize the roles of B10 cells in bacterial and aseptic heart injuries, address their regulatory functions in different stages of cardiovascular disorders, and discuss their challenges and opportunities in addressing cardiovascular diseases from bench to bedside.
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Zheng et al. (2023) conducted a review in Cardiovascular diseases. IL-10-producing regulatory B (B10) cells was evaluated. Interleukin-10-producing regulatory B cells play vital immunomodulatory roles in cardiovascular diseases, though their complex interplay with the immune system requires further clarification.
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