Elevated arterial stiffness (baPWV ≥1,750 cm/s) was associated with a significantly lower event-free survival rate for heart failure re-admission and cardiac death compared to low baPWV (P<0.05).
Cohort (n=72)
Does elevated arterial stiffness (measured by baPWV) predict re-admission or cardiac death in patients with heart failure?
Elevated arterial stiffness, measured by baPWV ≥1,750 cm/s, is a significant predictor of heart failure readmission and cardiac death.
p-value: p=<0.05
BACKGROUND: Arterial stiffness is used as an index of arteriosclerosis. The goal of this study was to clarify whether increased arterial stiffness, evaluated by measuring the brachial-ankle pulse wave velocity (baPWV), is a risk factor for the prognosis of heart failure (HF) patients. METHODS AND RESULTS: After examination of the baPWV, as well as the levels of neurohumoral factors, the 72 enrolled HF patients were followed up for a survival study, which had a primary endpoint of re-admission because of HF. The secondary endpoint was cardiac death. Results of Cox proportional hazards modeling revealed that baPWV, systolic blood pressure (BP) and brain natriuretic peptide level were factors that affected survival (P<0.05). The patients were divided into 2 groups according to the cutoff baPWV value (1,750 cm/s). Although hemodynamic factors were similar between the groups, the high-baPWV group had a lower event-free survival rate for the primary and secondary endpoints than the low-baPWV group (P<0.05). BP at re-admission was higher in the high-baPWV group (174+/-30 mmHg) than in the low-baPWV group (121+/-33 mmHg, P<0.01). CONCLUSIONS: Elevated arterial stiffness is a risk factor for re-admission or cardiac death of HF patients.
Meguro et al. (Thu,) conducted a cohort in Heart failure (n=72). High brachial-ankle pulse wave velocity (baPWV ≥1,750 cm/s) vs. Low baPWV (<1,750 cm/s) was evaluated on Re-admission because of HF (p=<0.05). Elevated arterial stiffness (baPWV ≥1,750 cm/s) was associated with a significantly lower event-free survival rate for heart failure re-admission and cardiac death compared to low baPWV (P<0.05).
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