Key result
Multiscale bidomain simulations demonstrated that variability in activation sequence and passive conduction properties explains a large part of the clinical variability in the human QRS complex.
Computational modeling demonstrates that variability in ventricular activation sequence and passive conduction properties explains a large part of the clinical variability observed in human QRS complex morphology.
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Advances mechanistic QRS modeling in research; leaves open clinical translation or patient-specific applications.
Cardone-Noott et al. (2016) studied Healthy and intraventricular block conditions. Multiscale bidomain simulations was evaluated on Impact of activation sequence characteristics on clinical QRS biomarkers. Multiscale bidomain simulations demonstrated that variability in activation sequence and passive conduction properties explains a large part of the clinical variability in the human QRS complex.
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