Key result
Longitudinal 3-day pSOFA scores improve mortality prediction AUC by ~6% vs admission scores.
Why the study?
Static pSOFA scores fail to capture changes in clinical condition or treatment response during a PICU stay, prompting evaluation of longitudinal pSOFA scores for dynamic mortality prediction.
Does longitudinal pSOFA scoring improve the prediction of 30-day in-hospital mortality compared to admission-day pSOFA score in PICU patients?
Cohort (n=9,146)
No
Does longitudinal pSOFA scoring improve the prediction of 30-day in-hospital mortality compared to admission-day pSOFA score in PICU patients?
Longitudinal pSOFA scores significantly improve the accuracy of 30-day in-hospital mortality prediction in PICU patients compared to using only the admission-day score.
Answers are grounded in this paper and cite their sources.
May improve PICU mortality prediction; leaves open need for prospective validation before clinical use.
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Akhondi‐Asl et al. (2024) conducted a cohort in Critically ill children in PICU (n=9,146). Longitudinal pSOFA scores vs. Admission-day pSOFA score was evaluated on AUC for predicting mortality between days 5 and 30 (AUC improvement 6.4%, 95% CI 6.3-6.6%). Longitudinal pSOFA scores from the first 3 days improved the AUC for predicting mortality between days 5 and 30 by 6.4% (95% CI, 6.3-6.6%) compared with the admission-day pSOFA score.
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