Key result
Advanced intracoronary imaging and cardiac PET improve early detection of cardiac allograft vasculopathy.
Advances in invasive and noninvasive imaging modalities improve the early detection of cardiac allograft vasculopathy, potentially optimizing targeted therapies to preserve graft function.
Cardiac allograft vasculopathy (CAV) is a type of coronary artery disease unique to heart transplant recipients that can result from chronic rejection of the transplanted heart. CAV is a major cause of morbidity and mortality after the first year of transplantation. Both immune and nonimmune mechanisms contribute to the initiation and progression of CAV and result in intimal thickening, fibrosis with luminal stenosis, chronic myocardial ischemia and eventual graft failure. Recent advances in imaging modalities-including invasive intracoronary imaging and noninvasive imaging with cardiac positron emission tomography-have improved the early detection of CAV and may allow for optimization of CAV-targeted therapies to reduce CAV progression and ultimately preserve graft function.
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Stomberski et al. (2025) conducted a review in Cardiac allograft vasculopathy. Recent advances in imaging modalities, including invasive intracoronary imaging and cardiac PET, have improved the early detection of cardiac allograft vasculopathy.
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