Key result
Fragmented QRS in acute PE linked to more cardiogenic shock, in-hospital death, and advanced treatments.
Why the study?
Different ECG characteristics can predict prognosis in acute pulmonary embolism, prompting evaluation of the relative frequency and prognostic value of fragmented QRS.
Does the presence of fragmented QRS on ECG predict adverse outcomes in patients hospitalized with acute pulmonary embolism?
Observational (n=106)
Does the presence of fragmented QRS on ECG predict adverse outcomes in patients hospitalized with acute pulmonary embolism?
The presence of fragmented QRS on the ECG of patients with acute pulmonary embolism is a significant predictor of cardiogenic shock, in-hospital mortality, and the need for advanced therapies.
Answers are grounded in this paper and cite their sources.
May support ECG risk stratification in acute PE; leaves open independent value beyond established markers.
Background: Acute pulmonary embolism can quickly cause hemodynamic collapse and death. Recent studies have shown that different characteristics of electrocardiogram (ECG) can be used to predict the prognosis of patients. This study aimed to investigate the relative frequency of fragmented QRS in the ECG of patients with pulmonary embolism and its prognostic value. Methods: This study was conducted retrospectively. The files of 106 patients hospitalized with a diagnosis of pulmonary embolism from January 2016 to the end of March 2020 were selected and reviewed. The findings of the ECG, including the ST elevation in V1-V4 leads with and without T invention, right axis deviation, right bundle branch block (RBBB), PR, QRS, QTc intervals, type of treatment (thrombolysis or embolectomy), cardiogenic shock, mortality were collected. Finally, the data were recorded and analyzed in SPSS software Version 16 Results: Hypertension, dyslipidemia, and diabetes mellitus were the most frequent risk factors among the patients. The relative frequency of fragmented QRS, at least in one lead, was 26.2%. The use of thrombolysis, mechanical ventilation, embolectomy, cardiogenic shock, and in-hospital death was significantly higher among patients who had fragmented QRS (P<0.001). CTNI was significantly higher in patients with fragmented QRS (P=0.001). In patients with fragmented QRS large vessels, involvement was significantly higher. Conclusion: This study showed that the presence of fragmented QRS in the ECG of acute embolism patients has a significant relationship with cardiogenic shock, hospital mortality, and the need for advanced treatment methods such as intubation, embolectomy, and the use of thrombolysis.
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Dehghani et al. (2025) conducted an observational in Acute pulmonary embolism (n=106). Fragmented QRS on ECG vs. Absence of fragmented QRS was evaluated on Cardiogenic shock, in-hospital death, and need for advanced treatment (p=<0.001). Fragmented QRS on the ECG of acute pulmonary embolism patients was significantly associated with higher rates of cardiogenic shock, in-hospital death, and need for advanced treatments (P<0.001).
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