Key result
Patients with childhood-onset Type I diabetes reporting the fewest depressive symptoms at baseline were least likely to develop coronary heart disease over 10 years.
Why the study?
Does depressive symptomatology increase the risk of developing coronary heart disease in patients with childhood-onset Type I diabetes?
Cohort (n=658)
Does depressive symptomatology increase the risk of developing coronary heart disease in patients with childhood-onset Type I diabetes?
Depressive symptoms are associated with an increased risk of developing coronary heart disease in patients with Type I diabetes, with potential mechanisms including insulin resistance, inflammation, and autonomic dysregulation.
Depressive symptoms may mark higher CHD risk in childhood-onset T1D; hypothesis-generating, prospective trials needed before practice change.
Recent evidence has suggested that depressive symptomatology is a risk factor for the development of coronary heart disease (CHD) in patients with diabetes mellitus, although little is understood about mechanisms that may explain this association. The Pittsburgh Epidemiology of Diabetes Complications (EDC) Study is a natural history study of 658 men and women with childhood-onset Type I diabetes. Participants from the EDC Study who reported the fewest depressive symptoms on the Beck Depression Inventory at baseline examination were least likely to develop CHD over 10 years. Differences in insulin resistance, autonomic dysregulation, inflammation, smoking, and complications associated with Type I diabetes appear to help explain this relationship. Future research should clarify causal pathways between depressive symptomatology, behavioral and physiological processes, and CHD.
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Kinder et al. (2002) conducted a cohort in Type I diabetes mellitus (n=658). Depressive symptomatology vs. Fewest depressive symptoms was evaluated on Development of coronary heart disease (CHD). Patients with childhood-onset Type I diabetes reporting the fewest depressive symptoms at baseline were least likely to develop coronary heart disease over 10 years.
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