Key result
ASCVD linked to ~5% higher odds of worse general health scores and mental disorders.
Why the study?
Atherosclerotic cardiovascular disease is a major cause of mortality worldwide, prompting investigation into the relationship between the 10-year ASCVD risk score and mental disorders.
Is the presence of ASCVD or a 10-year ASCVD risk score ≥ 5% associated with an increased risk of mental disorders?
Cross-Sectional (n=1,154)
No
Is the presence of ASCVD or a 10-year ASCVD risk score ≥ 5% associated with an increased risk of mental disorders?
Both established ASCVD and an elevated 10-year ASCVD risk score (≥ 5%) are significantly associated with worse mental health status, including anxiety, insomnia, and severe depression.
Answers are grounded in this paper and cite their sources.
ASCVD was associated with worse mental health; cross-sectional data leave causality and screening implications open for prospective study.
Atherosclerotic cardiovascular disease (ASCVD) is a major cause of mortality worldwide. This study aims to investigate the relationship between the 10-year ASCVD risk score and mental disorders.This study analyzed data from 1154 participants aged 25 to 70 enrolled in the Shiraz Heart Study cohort between 2016 and 2019. The ten-year ASCVD risk score was estimated using the ASCVD risk score estimator recommended by the American College of Cardiology and American Heart Association guidelines. Mental health was evaluated using a 28-item general health questionnaire concurrently with the ASCVD risk calculation. A multiple logistic regression model was employed for multivariate analysis. The mean age of participants was 44.25 ± 8.88 years, and most were men (n = 621, 53.8%). A multiple logistic regression model demonstrated that having ASCVD is associated with increased odds of somatic symptoms (OR 1.138, 95% CI 1.069-1.212), anxiety and insomnia (OR 1.113, 95% CI 1.043-1.188), severe depression (OR 1.173, 95% CI 1.084-1.269), and total general health scores (OR 1.053, CI 1.027-1.079). Another multiple logistic regression model showed that among participants without ASCVD, 10-year ASCVD risk score ≥ 5% is associated with increased odds of somatic symptoms (OR 1.126 95%CI 1.035-1.224), anxiety and insomnia (OR 1.117, 95% CI 1.031-1.211), social dysfunction (OR 1.121, 95% CI 1.034-1.215), severe depression (OR 1.195, 95% CI 1.078-1.324), and total general health scores (OR 1.068, CI 1.035-1.102). ASCVD and a 10-year ASCVD risk score ≥ 5 are associated with the development of mental disorders.
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Zibaeenezhad et al. (2026) conducted a cross-sectional in Atherosclerotic cardiovascular disease and mental disorders (n=1,154). Atherosclerotic cardiovascular disease (ASCVD) vs. Without ASCVD was evaluated on Total general health score (OR 1.053, 95% CI 1.027-1.079, p=<0.001). Atherosclerotic cardiovascular disease was significantly associated with increased odds of worse total general health scores (OR 1.053) and the development of mental disorders.
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