Key result
VirScan quantifies past viral exposures and shows precision medicine potential for immune-mediated diseases.
VirScan offers a high-throughput platform for comprehensive viral antibody profiling, with potential applications in understanding and managing chronic immune-mediated diseases.
May inform viral exposure assessment in immune diseases; leaves open clinical translation without prospective validation.
Phage immunoprecipitation sequencing (PhIP-Seq) is a high-throughput platform that uses programmable phage display for serology. VirScan, a specific PhIP-Seq library encoding viral peptides from all known human viruses, enables comprehensive quantification of past viral exposures. We review its use in immune-mediated diseases (IMDs), highlighting its utility in identifying viral exposures in the context of IMD development. Finally, we evaluate its potential for precision medicine by integrating it with other large-scale omics data sets.
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Shrewsbury et al. (2024) conducted a review in Immune-mediated diseases (IMDs). VirScan (PhIP-Seq) was evaluated. VirScan enables comprehensive quantification of past viral exposures and shows potential for precision medicine in immune-mediated diseases when integrated with large-scale omics data sets.
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