Why the study?
A lack of knowledge regarding molecular characteristics and genotype-phenotype correlations interferes with risk stratification and optimal treatment of Brugada syndrome in Vietnam.
Does the presence of SCN5A variants correlate with a higher risk of adverse clinical phenotypes in Vietnamese patients with Brugada syndrome?
Population
117 Vietnamese probands with Brugada syndrome
Comparison
SCN5A (+) group vs SCN5A (-) individuals
Design
Cohort study
Key result
Carrying any SCN5A variant was associated with a significantly higher risk of a family history of sudden cardiac death (RR 4.324; 95% CI 2.290-8.269; p<0.001) compared to SCN5A-negative individuals.
Authors
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SCN5A variants associated with higher SCD family history risk in Brugada syndrome; hypothesis-generating for risk stratification and needs prospective validation.
Observational (n=117)
Does the presence of SCN5A variants correlate with a higher risk of adverse clinical phenotypes in Vietnamese patients with Brugada syndrome?
Effect estimate: RR 4.324 (95% CI 2.290-8.269)
p-value: p=<0.001
In Vietnamese patients with Brugada syndrome, the presence of SCN5A variants is significantly associated with a higher risk of syncope, ventricular arrhythmias, and a family history of sudden cardiac death.
Pham et al. (2023) conducted an observational in Brugada syndrome (n=117). SCN5A variants vs. SCN5A (-) individuals was evaluated on Family history of sudden cardiac death (RR 4.324, 95% CI 2.290-8.269, p=<0.001). Carrying any SCN5A variant was associated with a significantly higher risk of a family history of sudden cardiac death (RR 4.324; 95% CI 2.290-8.269; p<0.001) compared to SCN5A-negative individuals.