Key result
Renal denervation reduced office systolic blood pressure by 17.6 mm Hg and 24-h ambulatory systolic blood pressure by 5.9 mm Hg at 6 months, though individual responses were highly variable.
Why the study?
Does renal denervation reduce blood pressure in patients with essential hypertension?
Meta-Analysis (n=109)
Open-label
Yes
Does renal denervation reduce blood pressure in patients with essential hypertension?
p-value: p=<0.001
Renal denervation provides modest reductions in ambulatory blood pressure at 6 months, though responses may be influenced by regression to the mean and require confirmation in randomized trials.
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Supports modest ambulatory BP reduction with renal denervation; extends meta-analytic data but leaves open need for randomized confirmation.
Persu et al. (2013) conducted a meta-analysis in Treatment-resistant essential hypertension (n=109). Renal denervation (RDN) vs. Baseline (within-group comparison) was evaluated on Change in office systolic blood pressure at 6 months (95% CI -22.0 to -13.1, p=<0.001). Renal denervation reduced office systolic blood pressure by 17.6 mm Hg and 24-h ambulatory systolic blood pressure by 5.9 mm Hg at 6 months, though individual responses were highly variable.
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