Key result
Periostin-expressing myofibroblasts in the injured heart derive from Tcf21+ tissue-resident fibroblasts and are necessary for adaptive healing and scar formation after myocardial infarction.
Myofibroblasts in the injured heart arise from Tcf21(+) tissue-resident fibroblasts and are necessary for adaptive healing and fibrosis.
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May inform strategies to enhance post-MI healing; leaves open translation from animal models to human therapeutics.
Kanisicak et al. (2016) studied Myocardial infarction and cardiac fibrosis. Genetic lineage tracing and targeted ablation of periostin+ myofibroblasts vs. Sham or uninjured controls was evaluated on Cellular origin and function of cardiac myofibroblasts. Periostin-expressing myofibroblasts in the injured heart derive from Tcf21+ tissue-resident fibroblasts and are necessary for adaptive healing and scar formation after myocardial infarction.
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