Key result
A weighted genetic risk score showed a significant interaction with obese/lean status for both triglycerides (P=2.87×10−4) and HDL cholesterol (P=1.05×10−3).
Why the study?
Does adiposity modify the effect of genetic risk scores on plasma triglyceride and HDL cholesterol concentrations?
Cohort
Does adiposity modify the effect of genetic risk scores on plasma triglyceride and HDL cholesterol concentrations?
Adiposity may modify genetic effects on TG/HDL; hypothesis-generating and should not yet change practice.
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Cole et al. (2014) conducted a cohort in Dyslipidemia. Weighted genetic risk score (GRS) vs. Obese versus lean status was evaluated on Interaction between obese/lean status and GRS for triglycerides and HDL cholesterol (p=2.87 × 10−4). A weighted genetic risk score showed a significant interaction with obese/lean status for both triglycerides (P=2.87×10−4) and HDL cholesterol (P=1.05×10−3).
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