Key result
Disruption of the KCNE3 gene in mice drastically reduced cAMP-stimulated electrogenic Cl- secretion across tracheal and intestinal epithelia, suggesting a role as a modifier gene in cystic fibrosis.
Disruption of the KCNE3 gene in mice reveals its essential role in cAMP-stimulated electrogenic Cl- secretion in intestinal and tracheal epithelia, suggesting it as a potential modifier gene in cystic fibrosis.
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Does not support clinical translation; leaves open KCNE3 as cystic fibrosis modifier for human validation.
Preston‐Ferrer et al. (2010) studied KCNE3 gene disruption. KCNE3 gene disruption vs. Wild-type mice was evaluated on cAMP-stimulated electrogenic Cl- secretion across tracheal and intestinal epithelia. Disruption of the KCNE3 gene in mice drastically reduced cAMP-stimulated electrogenic Cl- secretion across tracheal and intestinal epithelia, suggesting a role as a modifier gene in cystic fibrosis.
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