Key result
Atrial fibrillation was associated with a significantly higher prevalence of high-risk obstructive sleep apnea compared to general cardiology patients (68.2% vs 29.4%; OR 2.473, 95% CI 1.434-4.266).
Why the study?
OSA causes cardiovascular complications and AF increases risk of hospitalization and mortality, but the prevalence of AF patients at high risk for OSA required investigation.
Is there a higher prevalence of high-risk obstructive sleep apnea in patients with atrial fibrillation compared to general cardiology patients?
Cross-Sectional (n=545)
No
Is there a higher prevalence of high-risk obstructive sleep apnea in patients with atrial fibrillation compared to general cardiology patients?
Patients with atrial fibrillation have a significantly higher prevalence of high-risk obstructive sleep apnea compared to general cardiology patients, suggesting a need for routine OSA screening in this population.
Background: Obstructive Sleep Apnea (OSA) is a common respiratory disorder that causes intermittent upper airway collapse during sleep and can lead to various acute cardiovascular complications. Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of cardiovascular hospitalization and all-cause mortality. Our study aimed to investigate the prevalence of individuals with AF and those considered at high risk for OSA. Methods: A cross-sectional study was conducted with a population comprising patients who had visited KAUH cardiology clinics between 2017– 2019; subjects were categorized into AF patients and general cardiology patients. Patients were surveyed for OSA using the Berlin Questionnaire to assess the degree of OSA symptoms and to classify patients into high- or low-risk groups based on their responses. Results: Of the 656 patients, 545 met our inclusion criteria, of whom 192 were diagnosed with AF. Comparable demographic characteristics were observed between the AF and non-AF groups, barring higher rates of obesity ( p =0.001) and smoking ( p =0.042) in the AF group. The prevalence of high-risk OSA was significantly higher in AF patients (68.2%) compared to non-AF patients (29.4%), with an adjusted odds ratio of 2.473 times (95% CI: 1.434 − 4.266, p =0.001) greater for AF. The age, gender, and BMI categories did not differ significantly between the two groups. Binary logistic regression revealed significant associations between OSA and risk factors such as asthma (OR=4.408, 95% CI: 2.634– 7.376, p=0.001). Conclusion: These results serve to display a statistically significant increase in high-risk OSA in existing AF patients, irrespective of the presence of conventional OSA risk factors; this could imply a more immediate and direct relationship between both diseases and calls to include routine screening for OSA in patients diagnosed, newly or otherwise, with AF.
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Ibdah et al. (2024) conducted a cross-sectional in Atrial Fibrillation (n=545). Atrial Fibrillation vs. General cardiology patients (non-AF) was evaluated on Prevalence of high-risk Obstructive Sleep Apnea (OSA) (OR 2.473, 95% CI 1.434-4.266, p=0.001). Atrial fibrillation was associated with a significantly higher prevalence of high-risk obstructive sleep apnea compared to general cardiology patients (68.2% vs 29.4%; OR 2.473, 95% CI 1.434-4.266).
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