Key result
Triglyceride-rich lipoproteins and remnants causally drive ASCVD, highlighting targets to reduce residual risk.
This review provides a comprehensive overview of the metabolism of triglyceride-rich lipoproteins, highlighting their causal role in atherosclerotic cardiovascular disease and the mechanisms underlying hypertriglyceridemia.
Triglycerides are critical lipids as they provide an energy source that is both compact and efficient. Due to its hydrophobic nature triglyceride molecules can pack together densely and so be stored in adipose tissue. To be transported in the aqueous medium of plasma, triglycerides have to be incorporated into lipoprotein particles along with other components such as cholesterol, phospholipid and associated structural and regulatory apolipoproteins. Here we discuss the physiology of normal triglyceride metabolism, and how impaired metabolism induces hypertriglyceridemia and its pathogenic consequences including atherosclerosis. We also discuss established and novel therapies to reduce triglyceride-rich lipoproteins.
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Borén et al. (2021) conducted a review in Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease. Triglyceride-rich lipoproteins and their remnants are causally associated with atherosclerotic cardiovascular disease, highlighting the need for targeted therapies to reduce residual risk.
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