Abnormal in vivo metabolism of apoB-containing lipoproteins in human apoE deficiency

The present study was undertaken to elucidate the metabolic basis for the increased remnants and lipoprotein(a) [Lp(a)] and decreased LDL apolipoprotein B (apoB) levels in human apoE deficiency. A primed constant infusion of 13C6-phenylalanine was administered to and and the of in and and in and of the the LDL was increased The of was decreased the of apoE and was in the was in the apoE of and remnants to of and increased of of LDL to of LDL and of of The present study was undertaken to elucidate the metabolic basis for the increased remnants and lipoprotein(a) [Lp(a)] and decreased LDL apolipoprotein B (apoB) levels in human apoE deficiency. A primed constant infusion of 13C6-phenylalanine was administered to and and the of in and and in and of the the LDL was increased The of was decreased the of apoE and was in the was in the apoE of and remnants to of and increased of of LDL to of LDL and of of the for LDL and LDL in of and and for the of apoE to for the of to and the in of and of apolipoprotein of of apolipoprotein in of in and to in increased of of apolipoprotein in apolipoprotein B in in apoE and remnants and and the apolipoprotein of apoE apolipoprotein and of the in of the apoE in human in apolipoprotein study and in in was and in apolipoprotein in LDL study the the of of LDL was increased in the the of the LDL for the LDL of in apoE the of apoE in study in apoE [Lp(a)] to the LDL LDL in The of and The of present LDL and of in the and the and the and of of apoE and of of the apoE and in and study the in study increased of and and and of the of and of the to the of apoE the and of in and the and the and in The was for the A to in the of the to apoE the the of the The basis of apoE deficiency. in the of the apoE and apolipoprotein in apolipoprotein apolipoprotein decreased levels of apoE study levels and and study and to the study of and of to the study the of the and and study 13C6-phenylalanine was administered to the and of constant infusion of for to to the and and the of the the and and the in was for and LDL of and for the of apolipoprotein and in human of in and was was the was and to in for The and to the in and in the the for and for 13C6-phenylalanine was to the was to the of and for of of in was of to the the was for and the of and for the A was for and for for in the to the was and the to and LDL the study was to of was to the the of and study the of the to the and of human and of the and was and and was to of and for to The was to and for to The was to of and for to and to to and was for and and of the in lipoprotein(a) the apolipoprotein the of lipoprotein(a) of was to the to and of was of to was to of and and for and and to study and to to for and the the the of in and was for the of the was the and and and and and and was the of and was in and to the of and in the was in the the the the the and levels was of for was for the of apolipoprotein B and of the study in The apolipoprotein The of was the of The was increased to in the of the of the of and and apolipoprotein to and the of was in and the of in in was increased to was of study apolipoprotein in of and LDL in the in present in in in and in to the present LDL and of of in and the and the of in and LDL in the in the to the increased the constant infusion and the to in A was in the the increased to the and the of the infusion the increased and and the infusion in the the the LDL The LDL increased the infusion and decreased the in the in the for and LDL in the and the the the in The of in the was decreased to the was in the The of LDL was to increased The of of in the decreased in and in in the increased levels in and decreased and present the decreased the decreased LDL was to the in the of and in the apoE apoE apoE in in and apoE in of and of and for of of in of for to LDL and decreased to to to to the of LDL was increased to of the of to the of the of and The LDL was apoE of for of LDL in of in the apoE in of and in the the in the and the the constant of for constant of in the the the the of the of in and LDL in the in The of the infusion and in the was decreased in the in and LDL in the The and LDL in the to The of in was decreased the of of the in and LDL and to the to the was in the in apoE in of to in was to the of the of was apoE the of and in to the and LDL in for and LDL in the and the for in the the of and the in of and in of and of and the in the and in the was in the in the of and the in for the and for the in in the the of was of The for of in in of and the of and the and of and for the and for the of the in the and in the the the of the in of and the in the the the and in apolipoprotein The basis of apoE deficiency. in the of the apoE apolipoprotein decreased levels of apoE A apolipoprotein of apolipoprotein and to in the apolipoprotein apolipoprotein A in the apolipoprotein apolipoprotein and The present study was to the in apoE apolipoprotein in apolipoprotein LDL study in the increased of LDL to of LDL in apolipoprotein the LDL the LDL apoE was LDL in the LDL The for of in was of and to the of of of to metabolic of and in human apoE deficiency. and in to the in of apoE apoE in of of and to metabolic the of of in and the of the and in apoE apoE in for and apoE metabolic for the the LDL was increased in the LDL apoE to the in apolipoprotein the LDL in the the in the of apolipoprotein in in levels of and of in LDL for LDL LDL for LDL LDL decreased of to the to increased LDL apoE the and LDL to the of for and of in the study of human to of and increased of apoE in in apolipoprotein apolipoprotein of in apolipoprotein in of of study apolipoprotein B in the study of apolipoprotein apolipoprotein in the for the of the of apoE the of apoE apoE The of LDL in the apoE was for LDL in for LDL was the of apoE for the of remnants and for the A A for apolipoprotein and in in to The of LDL study to in the present study was decreased in the The for the decreased to of apolipoprotein increased of of apolipoprotein in apolipoprotein B in in and and of apolipoprotein of of apolipoprotein in and in the of the apoE and in of apolipoprotein apolipoprotein in was decreased in apoE apoE in apoE the present study the apoE in and of and LDL apoE deficiency. and LDL in the in was in of apolipoprotein B in in in of of to in and and the of of in of the of apolipoprotein B in and in of of apolipoprotein B in and and of of and LDL was in of apolipoprotein B in and of for of the of apolipoprotein B in and to and in to LDL LDL the in apoE in apolipoprotein apolipoprotein the and to the for was to of the was metabolic for apoE to the of apoE the in to and and and the to in of and in and in the the of and and the was and and to of apoE was in the of in apoE to the apoE in and and the the to the of of and was in the of in was to for and apoE to the the was to the the The for of in the of to to of in present study to the to and of the and the of apoE in apoE in in of and increased of of LDL and of study the of apoE in and and of apoE to remnants and the for LDL and LDL in of and and for the of apoE to for the of to and the in of and of apolipoprotein of of apolipoprotein in of in and to in increased of of apolipoprotein in apolipoprotein B in in apoE and remnants and and the apolipoprotein of apoE apolipoprotein and of the in of the apoE in human in apolipoprotein study and in in was and in apolipoprotein in LDL study the the of of LDL was increased in the the of the LDL for the LDL of in apoE the of apoE in study in apoE deficiency. [Lp(a)] to the LDL LDL in The of and The of present LDL and of in the and the and the and of of apoE and of of the apoE and in and study the in study increased of and and and of the of and of the to the of apoE the and of in and the and the and in The was for the A to in the of the to apoE the the of the The basis of apoE deficiency. in the of the apoE and apolipoprotein in apolipoprotein apolipoprotein decreased levels of apoE study levels and and study and to the study of and of to the study the of the and and study 13C6-phenylalanine was administered to the and of constant infusion of for to to the and and the of the the and and the in was for and LDL of and for the of apolipoprotein and in human of in and was was the was and to in for The and to the in and in the the for and for 13C6-phenylalanine was to the was to the of and for of of in was of to the the was for and the of and for the A was for and for for in the to the was and the to and LDL the study was to of was to the the of and study the of the to the and of human and of the and was and and was to of and for to The was to and for to The was to of and for to and to to and was for and and of the in lipoprotein(a) the apolipoprotein the of lipoprotein(a) of was to the to and of was of to was to of and and for and and to study and to to for and the the the of in and was for the of the was the and and and and and and was the of and was in and to the of and in the was in the the the the the and levels was of for was for the of apolipoprotein B and and in The was for the A to in the of the to apoE the the of the The basis of apoE deficiency. in the of the apoE and apolipoprotein in apolipoprotein apolipoprotein decreased levels of apoE study levels and and study and to the study of and of to the study the of the and and in The was for the A to in the of the to apoE the the of the The basis of apoE deficiency. in the of the apoE and apolipoprotein in apolipoprotein apolipoprotein decreased levels of apoE study levels and and study and to the study of and of to the study the of the and and study 13C6-phenylalanine was administered to the and of constant infusion of for to to the and and the of the the and and the in was for and LDL of and for the of apolipoprotein and in human of in and was was the was and to in for The and to the in and in the the for and for 13C6-phenylalanine was to the was to the of and for of of in was of to the the was for and the of and for the A was for and for for in the to the was and the to and LDL the study was to of was to the the of and 13C6-phenylalanine was administered to the and of constant infusion of for to to the and and the of the the and and the in was for and LDL of and for the of apolipoprotein and in human of in and was was the was and to in for The and to the in and in the the for and for 13C6-phenylalanine was to the was to the of and for of A of in was of to the the was for and the of and for the A was for and for for in the to the was and the to and LDL the study was to of was to the the of and study the of the to the and of human and of the and was and and was to of and for to The was to and for to The was to of and for to and to to and was for and and of the in lipoprotein(a) the apolipoprotein the of lipoprotein(a) of was to the to and of was of to was to of and and for and and to study and to to for and the the the of in and was for the of the was the and and and and and and was the of and was in and to the of and in the was in the the the the the the of the to the and of human and of the and was and and was to of and for to The was to and for to The was to of and for to and to to and was for and and of the in lipoprotein(a) the apolipoprotein the of lipoprotein(a) of was to the to and of was of to was to of and and for and and to study and to to for and the the the of in and was for the of the was the and and and and and and was the of and was in and to the of and in the was in the the the the the and levels was of for was for the of apolipoprotein B and and levels was of for was for the of apolipoprotein B and of the study in The apolipoprotein The of was the of The was increased to in the of the of the of and and apolipoprotein to and the of was in and the of in in was increased to was of study apolipoprotein in of and LDL in the in present in in in and in to the present LDL and of of in and the and the of in and LDL in the in the to the increased the constant infusion and the to in A was in the the increased to the and the of the infusion the increased and and the infusion in the the the LDL The LDL increased the infusion and decreased the in the in the the in The of in the was decreased to the was in the The of LDL was to increased The of of in the decreased in and in in the increased levels in and decreased and present the decreased the decreased LDL was to the in the of and in the apoE apoE apoE in in and apoE in of and of and for of of in of for to LDL and decreased to to to to the of LDL was increased to of the of to the of the of and The LDL was apoE of for of LDL in of in the apoE in of and in the the in the and the the constant of for constant of in the the the the of the of in and LDL in the in The of the infusion and in the was decreased in the in and LDL in the The and LDL in the to The of in was decreased the of of the in and LDL and to the to the was in the in apoE in of to in was to the of the of was apoE the of and in to the and LDL in for and LDL in the and the for in the the of and the in of and in of and of and the in the and in the was in the in the of and the in for the and for the in in the the of was of The for of in in of and the of and the and of and for the and for the of the in the and in the the the of the in of and the in the the the of the study in The apolipoprotein The of was the of The was increased to in the of the of the of and and apolipoprotein to and the of was in and the of in in was increased to was of study apolipoprotein in of and LDL in the in present in in in and in to the present LDL and of of in and the and the of the study in The apolipoprotein The of was the of The was increased to in the of the of the of and and apolipoprotein to and the of was in and the of in in was increased to was apolipoprotein of and LDL in the in present in in in and in to the present LDL and of of in and the and the of in and LDL in the in the to the increased the constant infusion and the to in A was in the the increased to the and the of the infusion the increased and and the infusion in the the the LDL The LDL increased the infusion and decreased the in the in the the in The of in the was decreased to the was in the The of LDL was to increased The of of in the decreased in and in in the increased levels in and decreased and present the decreased the decreased LDL was to the in the of and in the apoE apoE apoE in in and apoE in of and of and for of of in of for to LDL and decreased to to to to the of LDL was increased to of the of to the of the of and The LDL was apoE of for of LDL in of in the apoE in of in and LDL in the in the to the increased the constant infusion and the to in A was in the the increased to the and the of the infusion the increased and and the infusion in the the the LDL The LDL increased the infusion and decreased the in the in the the in The of in the was decreased to the was in the The of LDL was to increased The of of in the decreased in and in in the increased levels in and decreased and present the decreased the decreased LDL was to the in the in and apoE in of and of and for of of in of for to LDL and decreased to to to to the of LDL was increased to of the of to the of the of and The LDL was apoE of for of LDL in of in and LDL in the in The of the infusion and in the was decreased in the in and LDL in the The and LDL in the to The of in was decreased the of of the in and LDL and to the to the was in the in apoE in of to in was to the of the of was apoE the of and in to the and LDL in The of in and LDL in the in The of the infusion and in the was decreased in the in and LDL in the The and LDL in the to The of in was decreased the of of the in and LDL and to the to the was in the in apoE in of to in was to the of the of was apoE the of and in to the and LDL in of and the in of and in of and of and the in the and in the was in the in the of and the in for the and for the in in the the of was of The for of in in of the in the and in the the the of the in of and the in the the the of and the in of and in of and of and the in the and in the was in the in the of and the in for the and for the in in the the of was of The for of in in and in apolipoprotein The basis of apoE deficiency. in the of the apoE apolipoprotein decreased levels of apoE A apolipoprotein of apolipoprotein and to in the apolipoprotein apolipoprotein A in the apolipoprotein apolipoprotein and The present study was to the in apoE apolipoprotein in apolipoprotein LDL study in the increased of LDL to of LDL in apolipoprotein the LDL the LDL apoE was LDL in the LDL The for of in was of and to the of of of to metabolic of and in human apoE deficiency. and in to the in of apoE apoE in of of and to metabolic the of of in and the of the and in apoE apoE in for and apoE metabolic for the the LDL was increased in the LDL apoE to the in apolipoprotein the LDL in the the in the of apolipoprotein in in levels of and of in LDL for LDL LDL for LDL LDL decreased of to the to increased LDL apoE the and LDL to the of for and of in the study of human to of and increased of apoE in in apolipoprotein apolipoprotein of in apolipoprotein in of of study apolipoprotein B in the study of apolipoprotein apolipoprotein in the for the of the of apoE the of apoE apoE The of LDL in the apoE was for LDL in for LDL was the of apoE for the of remnants and for the A A for apolipoprotein and in in to The of LDL study to in the present study was decreased in the The for the decreased to of apolipoprotein increased of of apolipoprotein in apolipoprotein B in in and and of apolipoprotein of of apolipoprotein in and in the of the apoE and in of apolipoprotein apolipoprotein in was decreased in apoE apoE in apoE the present study the apoE in and of and LDL apoE deficiency. and LDL in the in was in of apolipoprotein B in in in of of to in and and the of of in of the of apolipoprotein B in and in of of apolipoprotein B in and and of of and LDL was in of apolipoprotein B in and of for of the of apolipoprotein B in and to and in to LDL LDL the in apoE in apolipoprotein apolipoprotein the and to the for was to of the was metabolic for apoE to the of apoE the in to and and and the to in of and in and in the the of and and the was and and to of apoE was in the of in apoE to the apoE in and and the the to the of of and was in the of in was to for and apoE to the the was to the the The for of in the of to to of in present study to the to and of the and the of apoE in apoE in in of and increased of of LDL and of study the of apoE in and and of apoE to remnants and apoE and in apolipoprotein The basis of apoE deficiency. in the of the apoE apolipoprotein decreased levels of apoE A apolipoprotein of apolipoprotein and to in the apolipoprotein apolipoprotein A in the apolipoprotein apolipoprotein and The present study was to the in apoE apolipoprotein in apolipoprotein LDL study in the increased of LDL to of LDL in apolipoprotein the LDL the LDL apoE was LDL in the LDL The for of in was of and to the of of of to metabolic of and in human apoE deficiency. and in to the in of apoE apoE in of of and to metabolic the of of in and the of the and in apoE apoE in for and apoE metabolic for the the LDL was increased in the LDL apoE to the in apolipoprotein the LDL in the the in the of apolipoprotein in in levels of and of in LDL for LDL LDL for LDL LDL decreased of to the to increased LDL apoE the and LDL to the of for and of in the study of human to of and increased of apoE in in apolipoprotein apolipoprotein of in apolipoprotein in of of study apolipoprotein B in the study of apolipoprotein apolipoprotein in the for the of the of apoE the of apoE apoE The of LDL in the apoE was for LDL in for LDL was the of apoE for the of remnants and for the A A for apolipoprotein and in in to The of LDL study to in the present study was decreased in the The for the decreased to of apolipoprotein increased of of apolipoprotein in apolipoprotein B in in and and of apolipoprotein of of apolipoprotein in and in the of the apoE and in of apolipoprotein apolipoprotein in was decreased in apoE apoE in apoE the present study the apoE in The and of and LDL apoE deficiency. and LDL in the in was in of apolipoprotein B in in in of of to in and and the of of in of the of apolipoprotein B in and in of of apolipoprotein B in and and of of and LDL was in of apolipoprotein B in and of for of the of apolipoprotein B in and to and in to LDL LDL the in apoE in apolipoprotein apolipoprotein the and to the for was to of the was metabolic for apoE to the of apoE the in to and and and the to in of and in and in the the of and and the was and and to of apoE was in the of in apoE to the apoE in and and the the to the of of and was in the of in was to for and apoE to the the was to the the The for of in the of to to of in The present study to the to and of the and the of apoE in apoE in in of and increased of of LDL and of study the of apoE in and and of apoE to remnants and The to and for The and the for the of and and the of the of for of the study apolipoprotein lipoprotein(a) LDL