The link between insulin resistance, hyperinsulinemia and increased mortality risk

The analysis of the literature clearly shows that a chronic increase in circulating insulin levels associated with insulin resistance (IR) causes great damage to the body over time. In fact, insulininsulin levels are related to the development of type 2 diabetes, cardiovascular diseases, cellular senescence, cancer, and neurodegenerative diseases. This review of the literature aims to verify whether insulin resistance (IR) with associated hyperinsulinemia (Hyperins) may also be directly associated with an increase in cardiovascular, cancer, and all-cause mortality. This manuscript follows other manuscripts already published by our group on insulin resistance/hyperinsulinemia, which aim to convince the scientific community that it should be considered an important independent risk factor for various pathologies and, as such, should be screened in the general population and, consequently, promptly treated. Only studies that investigated a direct relation between the presence of IR or Hyperins with an increased risk of mortality, with precise analysis of large numbers and published in more impactful journals, were chosen. The analysis of the manuscripts thatthat address this topic shows a strong relation between IR/Hyperins and increased cardiovascular, cancer-specific, and all-cause mortality. Therefore, it is mandatory that scientific societies and health authorities of different nations face this serious problem.