Discordant Short- and Long-Term Outcomes Associated With Diabetes in Patients With Heart Failure: Importance of Age and Sex
Key result
Diabetes in heart failure patients was associated with lower 30-day but higher long-term mortality, with the greatest 5-year risk in women aged ≤65 years (HR 1.64; 95% CI 1.50-1.79).
Why the study?
Does diabetes affect short- and long-term mortality and readmission in patients hospitalized for the first time with heart failure?
Population
116,556 patients admitted to the hospital for the first time with heart failure in Scotland between 1986 and…
Comparison
Diagnosis of diabetes vs No diabetes
Design
Cohort
Follow-up
Up to 5 years
Authors
Discussion
Loading...
Member takes
Implication
May warrant closer long-term surveillance in diabetic HF patients, especially younger women; leaves open causal mechanisms and targeted interventions.
Study Design
Type
Cohort (n=116,556)
Multicenter
Yes
Structured PICO
Does diabetes affect short- and long-term mortality and readmission in patients hospitalized for the first time with heart failure?
P
Population
116,556 patients admitted to the hospital for the first time with heart failure in Scotland between 1986 and 2003.
I
Intervention
Diagnosis of diabetes
C
Comparator
No diabetes
O
Outcome
Case fatality (mortality) at 30 days, 1 year, and 5 yearshard clinical
Main Result
Effect estimate: HR 1.41 (95% CI 1.31-1.52)
Diabetes in heart failure patients is associated with a paradoxical lower 30-day mortality but significantly higher long-term mortality, particularly in younger women.
Cite This Study
MacDonald et al. (2008) conducted a cohort in Heart failure (n=116,556). Diabetes vs. No diabetes was evaluated on Mortality at 5 years (men aged ≤65 years) (HR 1.41, 95% CI 1.31-1.52). Diabetes in heart failure patients was associated with lower 30-day but higher long-term mortality, with the greatest 5-year risk in women aged ≤65 years (HR 1.64; 95% CI 1.50-1.79).