Key result
ICU drug-drug interactions are linked to a 24% rate of abnormal ECG changes.
Why the study?
The study was conducted to identify and analyze drug-associated ECG changes, monitor arrhythmias, and examine related patient risk factors in ICU patients receiving multiple medications.
What is the incidence and severity of drug-induced arrhythmias and ECG changes among ICU patients receiving multiple medications?
Observational (n=200)
No
What is the incidence and severity of drug-induced arrhythmias and ECG changes among ICU patients receiving multiple medications?
May support closer ECG monitoring in polypharmacy ICU patients; leaves open causal links and need for interventional trials.
Identify and analyze ECG changes associated with the use of multiple drugs, such as QT interval prolongation, ST-segment deviations, and other cardiac conduction abnormalities. Arrhythmia Assessment: Systematically monitor and record the occurrence of various arrhythmia, including atrial fibrillation, ventricular tachycardia, and bradycardia, among ICU patients receiving multiple medications. Investigate the correlation between the number and types of medications administered to ICU patients with the ecg changes occurring. Examine patient-specific risk factors, including age, comorbidities, electrolyte imbalances, and concomitant drug interactions, that contribute to drug-induced arrhythmia and ECG alterations. Assess the severity of ECG changes and consequences on length of ICU stays. A prospective observational study was carried out in the inpatient in ICU department of a tertiary care hospital. Total 200 patients were studied over a period of 6 months for monitoring arrhythmia and ECG changes due to drugs. ADRs were assessed using WHO causality scale and Hartwig severity scale
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Dattatraya et al. (2025) conducted an observational in ICU patients (n=200). ICU medications (polypharmacy) was evaluated on Abnormal ECG changes. Among 200 ICU patients, 52.5% experienced drug-drug interactions and 24% developed abnormal ECG changes, highlighting the high risk of drug-induced arrhythmias in critically ill populations.
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