Key result
Allele C of rs1333049 (p=0.008) and the ɛ2/ɛ4 genotype of APOE (p<0.0001) were significantly associated with the risk of myocardial infarction.
Why the study?
Cardiovascular risk is influenced by genetic factors, motivating an analysis of potential associations between specific genetic variants and the risk of myocardial infarction.
Are common variants of APOE, CETP, and the 9p21.3 chromosomal region associated with the risk of myocardial infarction?
Cohort (n=2,286)
Are common variants of APOE, CETP, and the 9p21.3 chromosomal region associated with the risk of myocardial infarction?
Specific genotypes of rs1333049 and APOE (ɛ2/ɛ4) are strongly associated with myocardial infarction risk and may be useful in genetic risk scores.
Answers are grounded in this paper and cite their sources.
These variants were associated with MI risk; hypothesis-generating and should not yet inform clinical decisions or genetic scores.
The individual risk of an unfavorable cardiovascular outcome is determined by genetic factors in addition to lifestyle factors. This study was aimed at analyzing possible associations of several genetic factors with the risk of myocardial infarction (MI). For our study, we selected genes that have been significantly associated with MI in meta-analyses: the chromosomal region 9p21.3, the CETP gene, and the APOE gene. In total, 2286 randomly selected patients were included. Rs708272 and rs429358 and rs7412 were analyzed using RT-PCR via the TaqMan principle, and rs1333049 vas analyzed via a commercial KASP assay. In our sample, the frequencies of alleles and genotypes were consistent with frequencies in comparable populations of Eastern and Western Europe. Allele C of rs1333049 was significantly associated with MI among males (p = 0.027) and in the whole study sample (p = 0.008). We also revealed a significant association of the ɛ2/ɛ4 genotype of APOE with MI among males (p < 0.0001) and in the whole study sample (p < 0.0001). Thus, among the tested polymorphisms, some genotypes of rs1333049 and rs429358 and rs7412 are the most strongly associated with MI and can be recommended for inclusion into a genetic risk score.
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Semaev et al. (2023) conducted a cohort in Myocardial Infarction (n=2,286). Genetic variants (APOE, CETP, 9p21.3) was evaluated on Myocardial infarction (p=0.008). Allele C of rs1333049 (p=0.008) and the ɛ2/ɛ4 genotype of APOE (p<0.0001) were significantly associated with the risk of myocardial infarction.
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