Key result
Dual therapy manages ~41% of controlled stage II hypertension, while ACE inhibitors lead monotherapy.
Why the study?
Arterial hypertension requires constant monitoring of drug therapy to achieve target blood pressure, prompting an analysis of pharmacotherapy in patients achieving controlled disease.
Observational (n=274)
In general practice, controlled stage 2 hypertension is most frequently managed with dual therapy, predominantly utilizing ACE inhibitors.
Dual therapy predominates in controlled stage II hypertension; leaves open optimal regimens in general practice.
BACKGROUND: Arterial hypertension is a common cardiovascular disease that requires constant monitoring by a doctor of drug therapy to achieve the target blood pressure level. AIM: To analyze pharmacotherapy of essential hypertension in patients, who have achieved a controlled course of the disease. MATERIALS AND METHODS: In this study 274 patients with controlled course of stage 2 arterial hypertension and no comorbidities were recruited. Blood pressure indicators, anthropometric data, results of laboratory and instrumental studies, the volume of drug therapy for hypertension were analyzed. RESULTS: We analyzed 543 drug prescriptions for 274 patients with stage II hypertension. In 97 (35.3%) patients only one drug was prescribed, in 112 (40.7%) two drugs, in 46 (16.7%) three drugs from various pharmacological groups, among which monodrugs were in the lead: angiotensin-converting-enzyme inhibitors 31.86%, cardioselective -blockers 23%, angiotensin 2 receptor blockers 9.3%. Combined drugs were present in 18.4% of general doctors prescriptions. Fixed forms of combined antihypertensive drugs were taken by only 50 (18.4%) patients. To prevent cardiovascular complications of arterial hypertension, 75 (26%) patients were prescribed statins (atorvastatin or rosuvastatin) and 56 (19.5%) antiplatelet monotherapy with Cardiomagnyl, Thrombo ACC or clopidogrel. CONCLUSIONS: To achieve the target blood pressure level and control arterial hypertension in patients with stage II hypertension, general practitioners used all main
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Slobodyanyuk et al. (2023) conducted an observational in stage 2 arterial hypertension (n=274). Pharmacotherapy for essential hypertension was evaluated on Volume and type of drug therapy for hypertension. Among 274 patients with controlled stage II hypertension, 35.3% received monotherapy, 40.7% received two drugs, and ACE inhibitors were the most frequently prescribed monodrugs (31.86%).
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