Why the study?
Data on the association between family history, genetic factors, and coronary artery disease risk were limited in the Iranian population.
Does a positive family history of CAD predict increased severity and extent of coronary artery disease in adult patients presenting with typical chest pain and confirmed CAD?
Cross-Sectional (n=300)
Single-blind (outcome assessors)
Yes
Does a positive family history of CAD predict increased severity and extent of coronary artery disease in adult patients presenting with typical chest pain and confirmed CAD?
Odds Ratio: 2.22 (95% CI 1.2–4.06)
p-value: p=0.011
A positive family history of premature CAD is independently associated with more extensive and severe coronary involvement, emphasizing the need to incorporate familial history into clinical risk stratification and therapeutic decision-making.
Family history (FH) and genetic factors contribute significantly to coronary artery disease (CAD) risk. Given limited data on this association in the Iranian population, this study assessed CAD involvement patterns among patients with and without positive familial history. This cross-sectional study was conducted from April 2019 to April 2020 at Imam Reza and Ghaem Hospitals, Mashhad, Iran. We enrolled 300 patients who presented with typical chest pain and confirmed CAD via coronary angiography. Participants were divided into two groups based on FH of CAD and evaluated for potential risk factors. Of 300 patients, 170 had positive FH and 130 did not. The cohort included 175 males (58.3 %) with a mean age of 54.2 years. Multivariate logistic regression identified age (OR: 1.04, p = 0.014), male gender (OR: 0.56, p = 0.035), and hypertension (OR: 1.99, p = 0.008) as significant differentiators between FH groups. Positive FH was independently associated with more extensive CAD, including multivessel involvement and greater severity of disease. Positive familial history is strongly associated with increased severity and extent of CAD in Iranian patients. Incorporating FH into risk stratification can improve identification of high-risk individuals for targeted preventive and therapeutic strategies.
No takes yet. Share an insight, caveat, or question.
Bagheri et al. (2025) conducted a cross-sectional in Coronary artery disease (n=300). Positive family history of premature CAD vs. Negative family history of premature CAD was evaluated on Three-vessel coronary artery disease (adjusted OR 2.22, 95% CI 1.20-4.06, p=0.011).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: