Key result
Higher serum interleukin 18 levels were significantly associated with suicidal ideation in acute coronary syndrome patients only when they had concurrently lower serum serotonin levels.
Why the study?
The study investigated the effects of serum serotonin and interleukin 18 levels on suicidal ideation at acute and chronic phases of ACS.
Do serum serotonin and interleukin 18 levels predict suicidal ideation in patients with acute coronary syndrome?
Cohort (n=969)
No
Do serum serotonin and interleukin 18 levels predict suicidal ideation in patients with acute coronary syndrome?
Effect estimate: OR 1.23 (95% CI 0.89-1.70)
Absolute Event Rate: 22.1% vs 18.2%
Evaluating both serum serotonin and interleukin 18 levels during the acute phase of ACS may improve the clinical prediction of suicidal ideation, suggesting an interactive role between serotonergic and immune systems.
May enhance suicidal ideation risk assessment in ACS using combined IL-18 and serotonin levels; leaves open prospective validation.
Objective: We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS). Methods: Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the "suicidal thoughts" item of the Montgomery-Åsberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates. Results: Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group. Conclusion: By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved.
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Kim et al. (2023) conducted a cohort in Acute coronary syndrome (n=969). Serum interleukin 18 and serotonin levels vs. Higher vs lower median levels was evaluated on Suicidal ideation at baseline (higher vs lower interleukin 18) (OR 1.23, 95% CI 0.89-1.70). Higher serum interleukin 18 levels were significantly associated with suicidal ideation in acute coronary syndrome patients only when they had concurrently lower serum serotonin levels.
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