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Fractional flux rates of N τ -methylhistidine (3-methylhistidine; Me-His) of skin and gastrointestine were measured by administering [ methyl - 3 H]methionine to rats. 2. The results showed that the contribution of these tissues to urinary excretion of Me-His was at least 16.6 %. This means that when fractional catabolic rates of myosin and actin were estimated from urinary excretion of Me-His, the part of Me-His derived from skin and gastrointestine should not be neglected.
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Nishizawa et al. (1977) studied this question.
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