In a study of 30 patients histologic changes are described within the endocervix, which are associated with the use of oral contraceptives. Two lesions were found, the first of which has previously been called squamocolumnar prosoplasia or epidermidalization. This change, while not specific, was found in a high percentage of patients using these agents. The term “microglandular hyperplasia” is used to describe a second lesion which appears to occur only during pregnancy or with the use of oral contraceptives. The significance of these changes is discussed, with emphasis upon the fact that, while these changes may be mistaken histologically for adenocarcinoma, they are benign.
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Kyriakos et al. (1968) studied this question.