Sex differences in patterns of cardiovascular referral in patients with Marfan, Ehlers-Danlos, and Loeys-Dietz syndromes

Figures

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  Patients with hereditary connective tissue diseases and aortic pathology referred to cardiovascular medicine and cardiothoracic surgery.

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  Figure 1. Incidence of cardiovascular referral among patients with Marfan, Ehlers-Danlos, and Loeys-Dietz syndromes.

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  Figure 2. Proportion of patients referred to cardiovascular medicine (A) and cardiothoracic surgery (B) by connective tissue disease and sex.

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  Figure 3. Proportion of patients referred to cardiovascular medicine (A) and cardiothoracic surgery (B) among patients with aortic pathologies.

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  Figure 4. Proportion of patients referred to cardiovascular medicine (A) and cardiothoracic surgery (B) among patients with vascular type Ehlers-Danlos syndrome.

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  Figure E1. Calibration plot of entire patient cohort. This figure shows the calibration plot for the inverse propensity score weighting model applied to the entire patient cohort.

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  Figure E2. Histogram of propensity score of entire patient cohort. This figure shows the histogram of propensity scores for the inverse propensity score weighting model applied to the entire patient cohort.

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  Figure E3. Histogram of propensity scores by sex for entire patient cohort. This figure shows the histogram of propensity scores by sex for the inverse propensity score weighting model applied to the entire patient cohort.

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  Figure E4. Love plot of entire patient cohort. This figure displays the absolute standardized mean difference of the covariates used for inverse propensity score weighting applied to the entire patient cohort. BAV, Bicuspid aortic valve; CAD, coronary artery disease; EDS, Ehlers-Danlos syndrome; HTN, hypertension; LDS, Loeys-Dietz syndrome.

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  Figure E5. Calibration plot of patients with aortic pathologies. This figure shows the calibration plot for the inverse propensity score weighting model applied to the subgroup of patients with aortic pathologies.

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  Figure E6. Histogram of propensity scores for patients with aortic pathologies. This figure shows the histogram of propensity scores for the inverse propensity score weighting model applied to the subgroup of patients with aortic pathologies.

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  Figure E7. Histogram of propensity scores by sex for patients with aortic pathologies. This figure shows the histogram of propensity scores by sex for the inverse propensity score weighting model applied to the subgroup of patients with aortic pathologies.