Key result
Sleep disordered breathing early after acute myocardial infarction predicted a significant increase in right ventricular end-diastolic volume at 12 weeks (14% vs 0%; p=0.020).
Why the study?
Does sleep disordered breathing predict enlargement of the right heart in patients early after acute myocardial infarction?
Cohort (n=54)
Does sleep disordered breathing predict enlargement of the right heart in patients early after acute myocardial infarction?
Effect estimate: B-coefficient 0.315 (95% CI 0.013-0.617)
Absolute Event Rate: 14% vs 0%
p-value: p=0.041
Sleep disordered breathing diagnosed shortly after AMI is associated with an increase in right ventricular end-diastolic volume over the following 12 weeks, suggesting it contributes to right heart enlargement.
SDB post-AMI associated with RV enlargement; hypothesis-generating, prospective trials needed before screening or treatment implications.
Structural and functional integrity of the right heart is important in the prognosis after acute myocardial infarction (AMI). The objective of this study was to assess the impact of sleep disordered breathing (SDB) on structure and function of the right heart early after AMI. 54 patients underwent cardiovascular magnetic resonance 3-5 days and 12 weeks after AMI, and were stratified according to the presence of SDB, defined as an apnoea-hypopnoea index of ≥ 15 events · h(-1). 12 weeks after AMI, end-diastolic volume of the right ventricle had increased significantly in patients with SDB (n=27) versus those without (n=25) (mean ± sd 14 ± 23% versus 0 ± 17%, p=0.020). Multivariable linear regression analysis accounting for age, sex, body mass index, smoking, left ventricular mass and left ventricular end-systolic volume showed that the apnoea-hypopnoea index was significantly associated with right ventricular end-diastolic volume (B-coefficient 0.315 (95% CI 0.013-0.617); p=0.041). From baseline to 12 weeks, right atrial diastolic area increased more in patients with SDB (2.9 ± 3.7 cm(2) versus 1.0 ± 2.4 cm(2), p=0.038; when adjusted for left ventricular end systolic volume, p=0.166). SDB diagnosed shortly after AMI predicts an increase of right ventricular end-diastolic volume and possibly right atrial area within the following 12 weeks. Thus, SDB may contribute to enlargement of the right heart after AMI.
No takes yet. Share an insight, caveat, or question.
Büchner et al. (2014) conducted a cohort in Acute myocardial infarction (n=54). Sleep disordered breathing (SDB) vs. No sleep disordered breathing was evaluated on Increase in right ventricular end-diastolic volume (B-coefficient 0.315, 95% CI 0.013-0.617, p=0.041). Sleep disordered breathing early after acute myocardial infarction predicted a significant increase in right ventricular end-diastolic volume at 12 weeks (14% vs 0%; p=0.020).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: