Application of Huanglian Zicao Ointment in Anal Edema Associated with Chinese Medicine Rectal Instillation in Patients with Liver Cirrhosis

March 1, 2026Guangming Journal of Chinese Medicine

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Key Points

This research aims to observe the effectiveness of Huanglian Zicao Ointment in preventing anal edema associated with rectal instillation in liver cirrhosis patients.
Selected 60 liver cirrhosis patients treated at Henan University of Chinese Medicine from January 2018 to December 2020.
Randomly assigned patients into control (30) and observation groups (30).
The control group received paraffin oil with Chinese medicine rectal instillation while the observation group received Huanglian Zicao Ointment with rectal instillation for 10 days.
Before intervention, there were no significant differences in pain, anal distention, liquid retention time, bleeding, and anal edema between the two groups (P>0.05).
After intervention, the observation group showed significant improvement in anal edema and liquid retention time (P<0.05).
Huanglian Zicao Ointment notably reduced discomfort associated with anal edema, redness, ulceration, and bleeding compared to paraffin oil.

Demonstrates symptom relief from anal edema in liver cirrhosis patients using Huanglian Zicao Ointment, suggesting its significant benefits.

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LIU et al. (2026) studied this question.

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