On the cross-generational expression of psychiatric disorders: Commentary on Caspi et al. (2026).

The set of interwoven analyses across rich data sources by Caspi et al. (see record 2026-80066-001) are a compelling combination of theory and empirical research that establish new insights on how psychiatric disorder risk is shaped within and across families, and within and across the life course. Caspi et al. underscore that individuals with psychiatric disorders tend to couple, and that disorder risk in their offspring is clustered alongside the phenotypes exhibited by parents, but it is also transdiagnostic across many different disorders. Further, Caspi et al. show that across the life course, the expression of the liability inherited from parents is not only transdiagnostic but abundantly dynamic. (PsycInfo Database Record (c) 2026 APA, all rights reserved).