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May 1, 2026American Journal of TransplantationOpen Access

Metabolomic Atlas of Ischemia Reperfusion Injury in Human Lung Transplants – mitochondrial stress and primary graft dysfunction

Lubiao Liang Yajin Zhao Aizhou Wang Bohan Zhu Michael K. Hsin Marcelo Cypel Shaf Keshavjee Mingyao Liu

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Key Points

To explore the metabolic changes associated with ischemia reperfusion injury in human lung transplants and identify potential biomarkers for primary graft dysfunction.
Utilized metabolomic profiling to analyze lung tissues from human lung transplant patients.
Measured levels of metabolites, including glutathione and fatty acids.
Applied statistical analysis to assess the impact of ischemia reperfusion injury on metabolic profiles.
Identified significant alterations in levels of glutathione and long-chain fatty acids following ischemia reperfusion injury.
Found a correlation between metabolic changes and instances of primary graft dysfunction.
Indicated potential for targeted interventions to mitigate mitochondrial stress in lung transplant patients.

Implication

Investigates mitochondrial stress and primary graft dysfunction in lung transplantation, revealing potential biomarkers.

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Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/6a12955d48a0ea166567181c https://doi.org/10.1016/j.ajt.2026.04.007

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Integrated analysis and validation of metabolism-related genes in lung transplantation-induced cold ischemia/ reperfusion injuryOriginal Research · 2026
2Plasma metabolomic signatures of mitochondrial energetic disruption in severe primary graft dysfunction after heart transplantationOriginal Research · 2026 · 1 citations
3iTRAQ- and MRM-Based Proteomics Identify Early Injury Biomarkers for Primary Dysfunction After Liver TransplantationOriginal Research · 2026
4B100-07 Metabolome-wide Association Study Identifies Fatty Acid and Oxidative Stress Perturbations in Mesenchymal Cells From Subjects With Chronic Lung Allograft DysfunctionOriginal Research · 2026
5Biomarkers of Standard Criteria and Marginal Donor Lungs During Ex Vivo Lung Perfusion: A Comparative StudyOriginal Research · 2026

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